New Trends in Pharmacology & Drug Development
Aurora kinases control multiple events during cell cycle progression and are essential for mitotic and meiotic bipolar spindle assembly and function. There are three aurora kinases in mammals, some of which have oncogenic properties and all of which are overexpressed in multiple cancers 2.The kinetics of drug binding to gpcrs are complex and depend on several factors, including charge distribution on the receptor surface, ligand–receptor interactions in the binding channel and the binding site, or solvation. Previously, drugs were developed focusing on target affinity and selectivity. However, it is becoming evident that the drug–target residence time, related to the off-rate, is an important parameter for successful drug development. The residence time influences both the on-rate and overall effectiveness of drugs. Due to recent efforts in the development of fast computers, md simulations and related techniques allow calculation of the binding pathways of ligands and estimation of rate constants 3. Protease-activated receptors (pars) are a ubiquitously expressed class of g-protein-coupled receptors (gpcrs) that enable cells to respond to proteases in the extracellular environment in a nuanced and dynamic manner. Two agents targeting par1, recombinant activated protein c and vorapaxar, are US FDA approved. However, their use has been limited by questions of efficacy and safety, respectively.
- Binding kinetics and pathways of ligands to GPCRs
- Aurora A kinase ,a priority pharmaceutical target for treatment of cancer
- Novel adjuvants designed for improving vaccine efficacy
- Targetting Protease-activated receptors(PAR1)
- Risks associated with new drug development
Related Conference of New Trends in Pharmacology & Drug Development
13th Internationl Conference on Forensic Chemistry and Biochemistry
14th International Conference and Expo on Separation Techniques
4th International Conference on Petrochemistry and Natural Gas
New Trends in Pharmacology & Drug Development Conference Speakers
Recommended Sessions
- American Pharma
- Antibiotics
- Bio-America
- Cancer Studies: Drug Delivery and Chemistry
- Chem-Virology (Zika Virus)
- Chemical Biology
- ChemMedChem-Antimicrobials and Infectious Agents
- Computer Aided Drug Designing-CADD
- Drug Chemistry
- Emerging Infectious Diseases
- Frontiers in Chemistry
- Fusion of Traditional and BioMedicine
- Hyphenated Chromatographic Techniques
- Medicinal Chemistry & Drug Discovery
- Neurodegenerative Diseases
- New Trends in Pharmacology & Drug Development
- Novel Drug Discovery & Drug Delivery
- Novel Research: Hit to Lead
- Personalized Medicines and Drugs
- Pharmaceuticals & Nutraceuticals
- Plant Genomics
- Targeted Drug Delivery System-TDDS (Smart Drug Delivery)
- Vaccines and Autism
Related Journals
Are you interested in
- Advanced Food Processing Technologies - Food Chemistry Congress 2024 (Italy)
- Advanced Medicinal Chemistry - Chemistry Meeting-2025 (France)
- Advanced Organic & Inorganic Chemistry - Chemistry Meeting-2025 (France)
- Advanced synthetic polymers - BIOPOLYMER CONFERENCE 2024 (UAE)
- Advances in Chromatography Instrumentations - Chromatography Techniques-2024 (Canada)
- Advances in Chromatography-HPLC Instrumentations - Advanced Chromatography 2024 (Italy)
- Advances in Clinical Chemistry - Clinical Chemistry 2024 (Germany)
- Agricultural Chemistry - Chemistry Meeting-2025 (France)
- Agriculture and Resource Economics - Food Chemistry Congress 2024 (Italy)
- Analytical & Bio-analytical Applications of Chromatography - Advanced Chromatography 2024 (Italy)
- Analytical & Bio-analytical Applications of Chromatography - Chromatography Techniques-2024 (Canada)
- Analytical Chemistry - Chemistry Meeting-2025 (France)
- Anti-Infective Agents in Medicinal Chemistry - Medicinal Chemistry 2024 (Italy)
- Antibiotics - Medicinal Chemistry 2024 (Italy)
- Applications of Polymers in Medicine, Health and Biotechnology - BIOPOLYMER CONFERENCE 2024 (UAE)
- Applied Chemistry - Chemistry Meeting-2025 (France)
- Applied Medicinal Chemistry - Medicinal Chemistry 2024 (Italy)
- Bio economy and future of bio-based materials - BIOPOLYMER CONFERENCE 2024 (UAE)
- Bio-fertilizers - Medicinal Chemistry 2024 (Italy)
- Bio-fibers and Composite Materials - BIOPOLYMER CONFERENCE 2024 (UAE)
- Bio-polymer Manufacturing from Novel Resource - BIOPOLYMER CONFERENCE 2024 (UAE)
- Biochemical Applications of Chromatography - Chromatography Techniques-2024 (Canada)
- Biochemical Applications of Chromatography-HPLC - Advanced Chromatography 2024 (Italy)
- Biochemistry - Chemistry Meeting-2025 (France)
- Biocompatibility and Medical Applications - BIOPOLYMER CONFERENCE 2024 (UAE)
- Bioengineering and Novel Biomaterials - BIOPOLYMER CONFERENCE 2024 (UAE)
- Biologic Drugs in Autoimmune Diseases - Medicinal Chemistry 2024 (Italy)
- Biological Chemistry - Clinical Chemistry 2024 (Germany)
- Bioplastics and Biodegradation - BIOPOLYMER CONFERENCE 2024 (UAE)
- Biopolymers and Bioplastics - BIOPOLYMER CONFERENCE 2024 (UAE)
- Blood Gas Analysis - Clinical Chemistry 2024 (Germany)
- Chem-Corona (CoronaVirus) - Medicinal Chemistry 2024 (Italy)
- Chemical Engineering - Chemistry Meeting-2025 (France)
- Cheminformatics & Big Data in Chemistry - Chemistry Meeting-2025 (France)
- Chemistry in Clinical Research - Chemistry Meeting-2025 (France)
- Chip Based Chromatography Separations - Advanced Chromatography 2024 (Italy)
- Chip Based Chromatography Separations - Chromatography Techniques-2024 (Canada)
- Chromatography & Mass Spectrometry - Advanced Chromatography 2024 (Italy)
- Chromatography as Separation Techniques - Chromatography Techniques-2024 (Canada)
- Chromatography in Bio-Medical Research - Chromatography Techniques-2024 (Canada)
- Chromatography in Food Science Technology - Advanced Chromatography 2024 (Italy)
- Chromatography in Food Science Technology - Chromatography Techniques-2024 (Canada)
- Chromatography in Pharmacy & Pharmaceutical - Advanced Chromatography 2024 (Italy)
- Chromatography in Pharmacy & Pharmaceutical - Chromatography Techniques-2024 (Canada)
- Chromatography-HPLC as Separation Techniques - Advanced Chromatography 2024 (Italy)
- Chromatography-HPLC in Bio-Medical Research - Advanced Chromatography 2024 (Italy)
- Chromatography-Mass Spectroscopy Analysis - Chromatography Techniques-2024 (Canada)
- Clinical Biochemistry - Clinical Chemistry 2024 (Germany)
- Clinical Chemistry Methodologies - Clinical Chemistry 2024 (Germany)
- Clinical Endocrinology - Clinical Chemistry 2024 (Germany)
- Clinical Genomics - Clinical Chemistry 2024 (Germany)
- Clinical Hematology and Coagulation - Clinical Chemistry 2024 (Germany)
- Clinical Immunology - Clinical Chemistry 2024 (Germany)
- Clinical Metabolomics - Clinical Chemistry 2024 (Germany)
- Clinical Microbiology - Clinical Chemistry 2024 (Germany)
- Clinical Pharmacology - Clinical Chemistry 2024 (Germany)
- Clinical Toxicology - Clinical Chemistry 2024 (Germany)
- Computational Chemistry - Chemistry Meeting-2025 (France)
- Crystal engineering - Chemistry Meeting-2025 (France)
- Diagnostic Biomarkers - Clinical Chemistry 2024 (Germany)
- Drug Chemistry - Medicinal Chemistry 2024 (Italy)
- Drug Metabolism and Pharmacokinetics - Clinical Chemistry 2024 (Germany)
- Electrochemistry and Energy Storage - Chemistry Meeting-2025 (France)
- Environmental Chemistry and Geochemistry - Chemistry Meeting-2025 (France)
- Food Additives - Food Chemistry Congress 2024 (Italy)
- Food Adulteration - Food Chemistry Congress 2024 (Italy)
- Food Analysis - Food Chemistry Congress 2024 (Italy)
- Food and Flavor Chemistry - Chemistry Meeting-2025 (France)
- Food and Nutrition - Food Chemistry Congress 2024 (Italy)
- Food Authenticity and Integrity - Food Chemistry Congress 2024 (Italy)
- Food Chemistry - Food Chemistry Congress 2024 (Italy)
- Food Drug Analysis - Food Chemistry Congress 2024 (Italy)
- Food Engineering - Food Chemistry Congress 2024 (Italy)
- Food Nanotechnology - Food Chemistry Congress 2024 (Italy)
- Food Nutrition and Health - Food Chemistry Congress 2024 (Italy)
- Food Physical Chemistry - Food Chemistry Congress 2024 (Italy)
- Food Processing - Food Chemistry Congress 2024 (Italy)
- Food Rheology - Food Chemistry Congress 2024 (Italy)
- Food Science and Technology - Food Chemistry Congress 2024 (Italy)
- Food Toxicology - Food Chemistry Congress 2024 (Italy)
- Food Waste and Recycling - Food Chemistry Congress 2024 (Italy)
- Frontiers in Chemistry - Medicinal Chemistry 2024 (Italy)
- Fusion of Traditional and Biomedicine - Medicinal Chemistry 2024 (Italy)
- Green Chemistry - Chemistry Meeting-2025 (France)
- High Efficiency & High Resolution Techniques - Advanced Chromatography 2024 (Italy)
- High Efficiency & High Resolution Techniques - Chromatography Techniques-2024 (Canada)
- HPLC Fingerprinting in Bioinformatics & Computational Biology - Advanced Chromatography 2024 (Italy)
- HPLC Fingerprinting in Bioinformatics & Computational Biology - Chromatography Techniques-2024 (Canada)
- Hydro Colloids in Food Industry - Food Chemistry Congress 2024 (Italy)
- Hyphenated Chromatography Methods - Advanced Chromatography 2024 (Italy)
- Hyphenated Chromatography Methods - Chromatography Techniques-2024 (Canada)
- Industrial Chemistry - Chemistry Meeting-2025 (France)
- Major Chromatographic Techniques - Advanced Chromatography 2024 (Italy)
- Major Chromatographic Techniques - Chromatography Techniques-2024 (Canada)
- Market Growth of Chromatography - Chromatography Techniques-2024 (Canada)
- Market Growth of Chromatography-HPLC - Advanced Chromatography 2024 (Italy)
- Materials Chemistry - Chemistry Meeting-2025 (France)
- Medicinal Chemistry and Drug Discovery - Medicinal Chemistry 2024 (Italy)
- Method Development & Validation - Advanced Chromatography 2024 (Italy)
- Method Development & Validation - Chromatography Techniques-2024 (Canada)
- Nanotechnology and Nano polymers - BIOPOLYMER CONFERENCE 2024 (UAE)
- Natural Product Chemistry - Chemistry Meeting-2025 (France)
- Natural Product Chemistry - Chemistry Meeting-2025 (France)
- Natural Product Chemistry - Chemistry Meeting-2025 (France)
- Novel Target Drugs to the Treatment of Cancer - Medicinal Chemistry 2024 (Italy)
- Organic Chemistry - Food Chemistry Congress 2024 (Italy)
- Pharmaceutical Chemistry - Chemistry Meeting-2025 (France)
- Pharmaceuticals & Nutraceuticals - Medicinal Chemistry 2024 (Italy)
- Physical Chemistry - Chemistry Meeting-2025 (France)
- Plant Genomics - Medicinal Chemistry 2024 (Italy)
- Polymer Chemistry - Chemistry Meeting-2025 (France)
- Polymer Degradation and Waste Management - BIOPOLYMER CONFERENCE 2024 (UAE)
- Polymer Physics and Chemistry - BIOPOLYMER CONFERENCE 2024 (UAE)
- Polymer Processing and Modelling - BIOPOLYMER CONFERENCE 2024 (UAE)
- Recent Advances in Chromatography - Chromatography Techniques-2024 (Canada)
- Recent Advances in Chromatography-HPLC - Advanced Chromatography 2024 (Italy)
- Targeted Drug Delivery System-TDDS (Smart Drug Delivery) - Medicinal Chemistry 2024 (Italy)
- Theoretical Chemistry - Chemistry Meeting-2025 (France)
- Vaccines and Autism - Medicinal Chemistry 2024 (Italy)