Medicinal Chemistry, Drug Discovery & Drug Delivery

Hyphenated Chromatographic Techniques

Aurora kinases control multiple events during cell cycle progression and are essential for mitotic and meiotic bipolar spindle assembly and function. There are three aurora kinases in mammals, some of which have oncogenic properties and all of which are overexpressed in multiple cancers 2.The kinetics of drug binding to gpcrs are complex and depend on several factors, including charge distribution on the receptor surface, ligand–receptor interactions in the binding channel and the binding site, or solvation. Previously, drugs were developed focusing on target affinity and selectivity. One third of all drugs on the American market act on the same kind of important cell receptor -- the G protein-coupled receptors. A major mapping of these drugs has found that their pharmacological mechanisms are becoming more complex. The mapping also reveals rapid developments especially within Alzheimer's disease, obesity, asthma and diabetes.