Targeted Drug Delivery System-TDDS (Smart Drug Delivery)

The basic premise of a TDDS is to concentrate the drug in the tissues of interest while reducing the relative concentration of medication in other remaining tissues. As a result, the drug is localized to a greater degree on the targeted site while leaving surrounding tissues unaffected. Platinum-based (pt-based) anticancer drugs have been recognized as one of the most effective drugs for clinical treatment of malignant tumors due to its unique mechanism of action and broad range of anticancer spectrum. TDDS has several advantages for the treatment of disease quantitatively. For instance, drug localization, decreased side effects, reduced dosage, modulated pharmacokinetics, controlled bio-distribution, and most importantly, improved patient's compliance. The main objective and basic principle behind the concept of targeting is that, the specific drug receptor is targeted to fit and improve their binding affinity, to the specific receptor that ultimately will trigger the pharmacological activity.
 

  • Platinum based anticancer drugs
  • Objectives of TDDS
  • Bioligand and its attachement to protein target
  • Passive ,Inverse and Active approaches of targetting
  • Chemical and physical enhancer pathways

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