Medicinal Chemistry Aspects of Drug Action and Drug Metabolism

Medicinal Chemistry Understanding Drug Metabolism. These metabolic transformations are sometimes referred to as biotransformations. The body generally identifies drugs as foreign substances. Enzymes such as the Cytochrome P450 superfamily are heavily involved in the metabolism of foreign (xenobiotic) substances.

  • NS3, the protease of flaviviruses such as dengue and west Nile virus
  • Combined phenotypic/target-oriented screening approaches, and their application on anti-infective drug discovery
  • Targeting of host factors involved in virus replication
  • Biochemical mechanisms for the biotransformation of drugs and foreign compounds
  • Reaction mechanisms
  • Ultrastructural considerations,induction mechanisms, methodology, kinetics of inhibition
  • Activation, steroid and amine metabolism

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