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14th World Congress on Medicinal Chemistry and Drug Design, will be organized around the theme “A decade of Development on Medicinal Chemistry and Evolution of Fragment-based Drug Design”

Medicinal Chemistry 2019 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Medicinal Chemistry 2019

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Medicinal Chemistry for Drug Discovery: Significance of Recent Trends reviews the state of the art and aims to determine the significance of technology and market trends in medicinal chemistry for advancing productivity in drug discovery. Although the fundamental task of medicinal chemists has not changed drastically over time, the chemical and computational tools and perspectives at their disposal have advanced significantly. One in particular, fragment-based drug design, stands out as promising major improvements in research productivity. We examine medicinal chemistry-related approaches and methodologies that drug discovery organizations employ in an effort to increase productivity in early drug discovery and decrease attrition at later pipeline stages. Key topics considered include structure-based drug design, fragment-based drug design, natural products-based drug design, diversity-oriented synthesis, and chemogenomics. An overall assessment of the current and potential value of these approaches is presented. Various flavors of computer-aided drug design are also considered, as the complexity and limitations of drug discovery programs that are based on biochemical screens of large compound collections have been major factors in stimulating the growth of this modality.

 

  • Track 1-1Advances in medicinal chemistry
  • Track 1-2Medication plan and sub-atomic docking
  • Track 1-3Molecular modeling
  • Track 1-4Lead enhancement
  • Track 1-5Quantitative structure-activity relationship

Anti-Infective Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new anti-infective agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in anti-infective medicinal chemistry.  Anti-Infective Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in anti-infective drug discovery.

  • Track 2-1Chemotherapeutic agents
  • Track 2-2Toxicity, and therapeutic applications of antibiotics, antifungals, and antivirals
  • Track 2-3spectrum of coverage, resistance patterns
  • Track 2-4Mechanisms of action
  • Track 2-5Discovery of sulphonamides
  • Track 2-6Discovery of penicillin
  • Track 2-7Antimicrobialpeptides:Promising compounds against pathogenic microorganisms
  • Track 2-8Antimicrobialpeptides:Promising compounds against pathogenic microorganisms
  • Track 2-9Microorganisms that produce antibiotics
  • Track 2-10Chemical and biologic properties of agents used to prevent or treat infectious diseases

Formerly Current Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new anti-cancer agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in cancer medicinal chemistry. Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery

  • Track 3-1 Design and synthesis of target compounds: thiazoles, thiophenes, benzimidazoles and   boronic acid derivatives as anticancer and anti-diabetic agents
  • Track 3-2 Synthesis of neuroprotective and multi target directed ligand molecules and their pharmacokinetic/pharmacodynamic (PK/PD) studies
  • Track 3-3 Ionic liquid mediated C-C and C=C bond forming reactions
  • Track 3-4 Re purposing of existing drug molecules for improved PK/PD profiling by modification of non pharmacophoric parts
  • Track 3-5  Transition metal catalyzed C-H activation reactions of unreactive (C(sp2)-H, C(sp3)-H bond) for the synthesis of anticancer agents

Applied Medicinal Chemistry in its most common practice focusing on small organic molecules. Applied Medicinal Chemistry encompasses synthetic organic chemistry and aspects of natural products and computational chemistry in close combination with chemical biology, enzymology and structural biology, together aiming at the discovery and development of new therapeutic agents

 

  • Track 4-1Current advancements in pure and applied chemistry
  • Track 4-2Analytical chemistry
  • Track 4-3Organometallic chemistry
  • Track 4-4Applications of applied chemistry

Bioorganic & Medicinal Chemistry is a scientific journal focusing on the results of research on the molecular structure of biological organisms and the interaction of biological targets with chemical agents.

  • Track 5-1Medicinal chemistry in modern drug discovery
  • Track 5-2Natural products drug discovery
  • Track 5-3Drug discovery in preclinical research
  • Track 5-4Drug delivery and targeting
  • Track 5-5Nanotechnology in drug discovery

Medical biochemistry is a field that studies different types of molecules in hopes of bettering technology and medicine. In order to work in the medical biochemistry environment, students typically need to get an advanced degree, such as a master's and doctorate.

 

  • Track 6-1Potential use of stem cells for regeneration
  • Track 6-2Harnessing yeast organelles for metabolic engineering
  • Track 6-3Si-RNA a tool in chemical biology
  • Track 6-4Protomics         
  • Track 6-5Discovery of biomolecules through metagenomics

Medicinal Chemistry Research is a journal for the prompt disclosure of novel experimental achievements in the many facets of drug design, drug discovery, and the elucidation of mechanisms of action of biologically active compounds.

 

  • Track 7-1ADME (adsorption,distribution,metabolism and excretion)Of drugs
  • Track 7-2Metabolism and toxicology
  • Track 7-3Antiviral and antimicrobial activity
  • Track 7-4Drug receptor interaction
  • Track 7-5Kojic acid as a tyrosine inhibitor

Medicinal chemistry and pharmaceutical chemistry are disciplines at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with design, chemical synthesis and development for market of pharmaceutical agents, or bio-active molecules (drugs).Compounds used as medicines are most often organic compounds, which are often divided into the broad classes of small organic molecules (e.g., atorvastatin, fluticasone, clopidogrel) and "biologics" (infliximab, erythropoietin, insulin glargine), the latter of which are most often medicinal preparations of proteins (natural and recombinant antibodies, hormones, etc.). Inorganic and organometallic compounds are also useful as drugs (e.g., lithium and platinum-based agents such as lithium carbonate and cis-platin as well as gallium).In particular, medicinal chemistry in its most common practice—focusing on small organic molecules—encompasses synthetic organic chemistry and aspects of natural products and computational chemistry in close combination with chemical biology, enzymology and structural biology, together aiming at the discovery and development of new therapeutic agents. Practically speaking, it involves chemical aspects of identification, and then systematic, thorough synthetic alteration of new chemical entities to make them suitable for therapeutic use. It includes synthetic and computational aspects of the study of existing drugs and agents in development in relation to their bioactivities (biological activities and properties), i.e., understanding their structure-activity relationships (SAR). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for purpose of medicinal products.

 

  • Track 8-1Organometallic chemistry
  • Track 8-2Stereochemistry of organic compounds
  • Track 8-3Industrial inorganic chemistry
  • Track 8-4Bio inorganic compounds
  • Track 8-5Advanced trends in organic chemistry
  • Track 8-6Advances in medicinal chemistry

This paper provides a mini-review of some recent approaches for the treatment of brain pathologies examining both medicinal chemistry and pharmaceutical technology contributions. Medicinal chemistry-based strategies are essentially aimed at the chemical modification of low molecular weight drugs in order to increase their lipophilicity or the design of appropriate prodrugs, although this review will focus primarily on the use of prodrugs and not analog development. Recently, interest has been focused on the design and evaluation of prodrugs that are capable of exploiting one or more of the various endogenous transport systems at the level of the blood brain barrier (BBB). The technological strategies are essentially non-invasive methods of drug delivery to malignancies of the central nervous system (CNS) and are based on the use of nanosystems (colloidal carriers) such as liposomes, polymeric nanoparticles, solid lipid nanoparticles, polymeric micelles and dendrimers. The biodistribution of these nanocarriers can be manipulated by modifying their surface physico-chemical properties or by coating them with surfactants and polyethylene-glycols (PEGs). Liposomes, surfactant coated polymeric nanoparticles, and solid lipid nanoparticles are promising systems for delivery of drugs to tumors of the CNS. This mini-review discusses issues concerning the scope and limitations of both the medicinal chemistry and technological approaches. Based on the current findings, it can be concluded that crossing of the BBB and drug delivery to CNS is extremely complex and requires a multidisciplinary approach such as a close collaboration and common efforts among researchers of several scientific areas, particularly medicinal chemists, biologists and pharmaceutical technologists.

  • Track 9-1Medication plan and sub-atomic docking
  • Track 9-2Molecular modeling
  • Track 9-3Lead enhancement
  • Track 9-4Quantitative structure-activity relationship

Medicinal Chemistry — Understanding Drug Metabolism. These metabolic transformations are sometimes referred to as biotransformations. The body generally identifies drugs as foreign substances. Enzymes such as the Cytochrome P450 superfamily are heavily involved in the metabolism of foreign (xenobiotic) substances

 

  • Track 10-1NS3, the protease of flaviviruses such as dengue and west Nile virus
  • Track 10-2Combined phenotypic/target-oriented screening approaches, and their application on anti-infective drug discovery
  • Track 10-3Targeting of host factors involved in virus replication
  • Track 10-4Biochemical mechanisms for the biotransformation of drugs and foreign compounds
  • Track 10-5Reaction mechanisms
  • Track 10-6Ultrastructural considerations,induction mechanisms, methodology, kinetics of inhibition
  • Track 10-7Activation, steroid and amine metabolism

Medicinal chemistry and pharmaceutical chemistry are disciplines at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with design, chemical synthesis and development for market of pharmaceutical agents, or bio-active molecules (drugs).

 

  • Track 11-1How do antibiotics work?
  • Track 11-2What are the side effects?
  • Track 11-3Main types of antibiotics
  • Track 11-4Biological antibiotics derived from molds
  • Track 11-5Synthetic antibiotics derived from dyes

ADME is an abbreviation in pharmacokinetics and pharmacology for "absorption, distribution, metabolism, and excretion", and describes the disposition of a pharmaceutical compound within an organism. The four criteria all influence the drug levels and kinetics of drug exposure to the tissues and hence influence the performance and pharmacological activity of the compound as a drug. Sometimes, liberation and/or toxicity are also considered, yielding LADME, ADMET, or LADMET.

 

  • Track 12-1Role of computational biology
  • Track 12-2Drug delivery carriers
  • Track 12-3Pioneering digital health and smart drug delivery systems
  • Track 12-4Ligand binding studies
  • Track 12-5Phage display technology for clinical application of protein drugs
  • Track 12-6Molecular modeling
  • Track 12-7Lead enhancement
  • Track 12-8Quantitative structure-activity relationship

Organic compounds are important because all living organisms (redundant) contain carbon. The carbon energy cycle of carbohydrates in organisms but also in fossils fuels becoming petroleum and natural gas. Organic compounds are important because all living organisms (redundant) contain carbon. The three basic macromolecules of life are Carbohydrates (CH2O), Fats (lipids) (CHO) and Proteins (CHON).

 

  • Track 13-1Components of ADME
  • Track 13-2Pharmacokinetics
  • Track 13-3Process of ADME
  • Track 13-4Application of integrated data from the physical and biological sciences to problems of chemotherapy
  • Track 13-5Transport of drugs to site of action
  • Track 13-6Biotransformation of drugs
  • Track 13-7Interaction of drugs with enzyme systems
  • Track 13-8Recent advances in drug design
  • Track 13-9Medication plan and sub-atomic docking

Drug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is sometimes referred to as computer-aided drug design.

  • Track 14-1Elementary concepts of organic chemistry
  • Track 14-2Bioorganic chemistry
  • Track 14-3Catalysis of organic reactions
  • Track 14-4Inorganic & organometallic compounds
  • Track 14-5Chemical bonding & cheminformatics
  • Track 14-6Stereochemistry of organic compounds
  • Track 14-7Physical organic chemistry
  • Track 14-8Organic photochemistry

Chemical biology is a scientific discipline spanning the fields of chemistry and biology. The discipline involves the application of chemical techniques, analysis, and often small molecules produced through synthetic chemistry, to the study and manipulation of biological systems. In contrast to biochemistry, which involves the study of the chemistry of biomolecules and regulation of biochemical pathways within and between cells, chemical biology deals with chemistry applied to biology.

 

  • Track 15-1Ligand and structure based drug design
  • Track 15-2Computational chemistry
  • Track 15-3Enzyme as target
  • Track 15-4Receptor as target
  • Track 15-5QSAR/QSPR Quantitative structure activity/property relationships

Chemical biology is a scientific discipline spanning the fields of chemistry and biology. The discipline involves the application of chemical techniques, analysis, and often small molecules produced through synthetic chemistry, to the study and manipulation of biological systems. In contrast to biochemistry, which involves the study of the chemistry of biomolecules and regulation of biochemical pathways within and between cells, chemical biology deals with chemistry applied to biology.

 

  • Track 16-1Chemical biology of molecules
  • Track 16-2Chemical pharmacology
  • Track 16-3Medicinal companies and market analysis
  • Track 16-4Synthetic medicinal chemistry

Diagnostic specialties: Clinical laboratory sciences are the clinical diagnostic services that apply laboratory techniques to diagnosis and management of patients. In the United States, these services are supervised by a pathologist. The personnel that work in these medical laboratory departments are technically trained staff who do not hold medical degrees, but who usually hold an undergraduate medical technology degree, who actually perform the tests, assays, and procedures needed for providing the specific services. Subspecialties include transfusion medicine, cellular pathology, clinical chemistry, hematology, clinical microbiology and clinical immunology.

 

  • Track 17-1 Biological mass spectrometry 
  • Track 17-2Modern ionization methods and mass analyzers
  • Track 17-3 Small molecule structure assignment
  • Track 17-4Quantitative assay development by LC-MS and metabolomics quantitative discovery-based proteomics and validation methods
  • Track 17-5 Peptide sequence determination
  • Track 17-6Post-translational modification mapping
  • Track 17-7Protein structure determination methods

Drug delivery devices are specialized tools for the delivery of a drug or therapeutic agent via a specific route of administration. Such devices are used as part of one or more medical treatments. A medical device is defined within the Food Drug & Cosmetic Act as " an instrument, apparatus, implement, machine, contrivance, implant, in vitro reagent, or other similar or related article, including a component part, or accessory which is: recognized in the official National Formulary, or the United States Pharmacopoeia, or any supplement to them, intended for use in the diagnosis of disease or other conditions, or in the cure, mitigation, treatment, or prevention of disease, in man or other animals, or intended to affect the structure or any function of the body of man or other animals, and which does not achieve any of it's primary intended purposes through chemical action within or on the body of man or other animals and which is not dependent upon being metabolized for the achievement of any of its primary intended purposes.

 

  • Track 18-1Anaesthetic vaporizer
  • Track 18-2Tinctures‎ 
  • Track 18-3Transdermal patches‎ 
  • Track 18-4Nasal sprays‎ 
  • Track 18-5Micro dispensing

Targeted drug delivery, sometimes called smart drug delivery,is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others. It is a special form of drug delivery system where the medicament is selectively targeted or delivered only to its site of action or absorption and not to the non-target organs or tissues or cells.

 

  • Track 19-1Nanotechnology in drug discovery
  • Track 19-2Medicinal chemistry in modern drug discovery
  • Track 19-3Natural products drug discovery
  • Track 19-4Medicinal chemistry in modern drug discovery
  • Track 19-5Novel drug discovery & drug delivery

Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. It may involve scientific site-targeting within the body, or it might involve facilitating systemic pharmacokinetics. Drug delivery technologies modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance.

 

  • Track 20-1Platinum based anticancer drugs
  • Track 20-2Objectives of TDDS
  • Track 20-3Bioligand and its attachement to protein target
  • Track 20-4Passive, inverse and active approaches of targeting
  • Track 20-5Chemical and physical enhancer pathways