Advances in Medicinal Chemistry

This paper provides a mini-review of some recent approaches for the treatment of brain pathologies examining both medicinal chemistry and pharmaceutical technology contributions. Medicinal chemistry-based strategies are essentially aimed at the chemical modification of low molecular weight drugs in order to increase their lipophilicity or the design of appropriate prodrugs, although this review will focus primarily on the use of prodrugs and not analog development. Recently, interest has been focused on the design and evaluation of prodrugs that are capable of exploiting one or more of the various endogenous transport systems at the level of the blood brain barrier (BBB). The technological strategies are essentially non-invasive methods of drug delivery to malignancies of the central nervous system (CNS) and are based on the use of nanosystems (colloidal carriers) such as liposomes, polymeric nanoparticles, solid lipid nanoparticles, polymeric micelles and dendrimers. The biodistribution of these nanocarriers can be manipulated by modifying their surface physico-chemical properties or by coating them with surfactants and polyethylene-glycols (PEGs). Liposomes, surfactant coated polymeric nanoparticles, and solid lipid nanoparticles are promising systems for delivery of drugs to tumors of the CNS. This mini-review discusses issues concerning the scope and limitations of both the medicinal chemistry and technological approaches. Based on the current findings, it can be concluded that crossing of the BBB and drug delivery to CNS is extremely complex and requires a multidisciplinary approach such as a close collaboration and common efforts among researchers of several scientific areas, particularly medicinal chemists, biologists and pharmaceutical technologists.

 

  • Medication plan and sub-atomic docking
  • Molecular modeling
  • Lead enhancement
  • Quantitative structure-activity relationship

Related Conference of Advances in Medicinal Chemistry

May 24-25, 2022

11th World Congress on Chromatography

Prague, Czech Republic
July 04-05, 2022

11th World Congress on Mass Spectrometry

London, UK
July 14-15, 2022

"12th World Congress on Green Chemistry and Technology"

Amsterdam, Netherlands
July 18-19, 2022

18th European Organic Chemistry Congress

Amsterdam, Netherlands
August 01-02, 2022

12th European Chemistry Congress

Rome, Italy
September 01-02, 2022

World Summit on Organic and Inorganic Chemistry

Dublin, Ireland
September 01-02, 2022

World Congress on Chemistry and Chemical Technologies

Ireland, Dublin
September 12-13, 2022

2nd World Congress on Plasma Chemistry and Plasma Processing

Prague, Czech Republic
September 12-13, 2022

11th Global Summit on Mass Spectrometry

, Australia
September 23-24, 2022

15th International conference on Chemistry

London, UK
October 17-18, 2022

International Conference on Drug Discovery and Development

Stockholm, Sweden
October 17-18, 2022

International Conference on Pharmacognosy

Stockholm, Sweden
October 24-25, 2022

20th International Conference on Electrochemistry

Dublin, Ireland
October 24-25, 2022

26th International Conference on Organic & Inorganic Chemistry

Zurich, Switzerland
October 24-25, 2022

23rd International Conference on Green Chemistry and Technology

Zurich, Switzerland
October 24-25, 2022

2nd International Conference on Analytical Chemistry

Paris, France
November 07-08, 2022

7thnternational Conference on Polymer Chemistry

London, UK
November 07-08, 2022

12th World Congress on Chemistry

London, UK
November 14-15, 2022

12th International Conference on Chemistry 

London, UK
November 22-23, 2022

4th International Conference on Chemistry Education and Research

Singapore City, Singapore
December 07-08, 2022

11th International Conference on Nuclear and Radiochemistry

Barcelona, Spain

Advances in Medicinal Chemistry Conference Speakers

Recommended Sessions

Related Journals

Are you interested in