Advances in Medicinal Chemistry

This paper provides a mini-review of some recent approaches for the treatment of brain pathologies examining both medicinal chemistry and pharmaceutical technology contributions. Medicinal chemistry-based strategies are essentially aimed at the chemical modification of low molecular weight drugs in order to increase their lipophilicity or the design of appropriate prodrugs, although this review will focus primarily on the use of prodrugs and not analog development. Recently, interest has been focused on the design and evaluation of prodrugs that are capable of exploiting one or more of the various endogenous transport systems at the level of the blood brain barrier (BBB). The technological strategies are essentially non-invasive methods of drug delivery to malignancies of the central nervous system (CNS) and are based on the use of nanosystems (colloidal carriers) such as liposomes, polymeric nanoparticles, solid lipid nanoparticles, polymeric micelles and dendrimers. The biodistribution of these nanocarriers can be manipulated by modifying their surface physico-chemical properties or by coating them with surfactants and polyethylene-glycols (PEGs). Liposomes, surfactant coated polymeric nanoparticles, and solid lipid nanoparticles are promising systems for delivery of drugs to tumors of the CNS. This mini-review discusses issues concerning the scope and limitations of both the medicinal chemistry and technological approaches. Based on the current findings, it can be concluded that crossing of the BBB and drug delivery to CNS is extremely complex and requires a multidisciplinary approach such as a close collaboration and common efforts among researchers of several scientific areas, particularly medicinal chemists, biologists and pharmaceutical technologists.

  • Medication plan and sub-atomic docking
  • Molecular modeling
  • Lead enhancement
  • Quantitative structure-activity relationship

Related Conference of Advances in Medicinal Chemistry

January 30-31, 2019

2nd World Congress on Petrochemistry

Bangkok, Thailand
February 22-23, 2019

20th Chemistry Education on Analytical & Medicinal Drug Discovery

San Francisco, CA, USA
March 18-19, 2019

5th International Conference on Polymer Chemistry

Amsterdam, Netherlands
March 20-21, 2019

19th Global Chemistry Conference

New York, USA
March 25-26, 2019

25th World Congress on Chemistry

Hong Kong
26-27th April, 2019

22nd International Conference on Past and Present Research Systems on Green Chemistry

Vancouver, British Columbia, Canada
April 26-27, 2019

18th International Conference on Industrial Chemistry &
Water Treatment

Vancouver, British Columbia
May 09-10, 2019

10th International Conference on Chemistry

Amsterdam, Netherlands
May 27- 28, 2019

13th International Conference on Electrochemistry

Barcelona, Spain
May 29-30,2019

12thAnnual Congress on Chemistry

| Four Points by Sheraton | Taipei, Taiwan
May 29-30, 2019

8th Global Congress on Mass Spectrometry

Four Points by Sheraton | Taipei, Taiwan
June 10-11, 2019

14th World Congress on Medicinal Chemistry and Drug Design

Edinburgh, Scotland
June 10-11, 2019

8th World Congress on Mass Spectrometry

Edinburgh | Scotland
June 12-13, 2019

Materials Chemistry Summit 2019

| Montreal, Quebec, Canada
June 17-18, 2019

9th European Chemistry Congress

Berlin, Germany
July 05-06, 2019

25th World Chemistry & Systems Biology Conference

Columbus, Ohio, USA
September 27 28, 2019

29th International conference onDrug Designing & Medicinal Drug Discovery

Toronto, Ontario, Canada
August 08-09, 2019

6th International Conference on Organic and Inorganic Chemistry

Amsterdam, Netherlands
August 28-29, 2019

10th World Meet on Analytical Chemistry & Instrumentation

Bangkok, Thailand
September 09-10, 2019

6th International Conference on Physical and Theoretical Chemistry

Zurich, Switzerland
September 09-10, 2019

International Congress on Advances in Organic & Inorganic Chemistry

| Holiday Inn Atrium | Singapore
September 19-20, 2019

6thAnnual Meeting on Organic and Inorganic Chemistry

Osaka, Japan
25-26th September, 2019

CADD & Drug Delivery

Toronto, Ontario, Canada
October 10-11, 2019

11th World Congress on Chemistry

Stockholm, Sweden

Advances in Medicinal Chemistry Conference Speakers

Recommended Sessions

Related Journals

Are you interested in