Daniel Becker earned his PhD at Indiana University in Bloomington, Indiana and worked in the pharmaceutical industry in Searle, Pharmacia, and then Pfizer as a Project Leader and Research Fellow developing new treatments for cancer, arthritis, and cardiovascular diseases. He moved from industry to join Loyola University Chicago in 2004 where he serves as a full Professor of Chemistry performing research in synthetic organic and medicinal chemistry, especially in the discovery of new antibiotics and treatments for cancer, as well as in supramolecular chemistry. He has published more than 50 scientific papers in various areas of chemistry and is an inventor on over 50 U.S. patents.
Our research is focused on the design and synthesis of metalloenzyme inhibitors and also of serine protease and serine hydrolase inhibitors with antibiotic properties. In addition, we are interested in the synthesis and conformational dynamics of supramolecular scaffolds related to cyclotriveratrylene (CTV) with applications in host-guest chemistry. Other active research areas involve synthetic methodology including cascade reactions and metal-catalyzed functionalization reactions.
Orazio Nicolotti is Professor of Medicinal Chemistry at the University of Bari. Major interests in molecular and data modeling, drug design, QSAR, predictive toxicology, combinatorial library design, evolutionary algorithms, docking and molecular dynamics. So far, author of 99 research papers, 7 book chapters, 1 international patent. Editor of the book “Computational toxicology” published in 2018 by Humana Press. Principal investigator of many research funded projects and industrial agreements for technology transfer.
Computer Aided Drug Designing