Cancer Studies: Drug Delivery Chemistry

Cancer is defined as an uncontrolled growth of abnormal cells. Current treatment strategies for cancer include combination of radiation, chemotherapy and surgery. The long-term use of conventional drug delivery systems for cancer chemotherapy leads to fatal damage of normal proliferate cells and this is particularly used for the management of solid tumours, where almost tumour cells are not invaded quickly. A targeted drug delivery system (TDDS) is a system, which releases the drug at a preselected bio site in a controlled manner. Nanotechnology based delivery systems are making a significant impact on cancer treatment and the polymers play key role in the development of nanopraticlulate carriers for cancer therapy. Some important technological advantages of nanotherapeutic drug delivery systems (NDDS) include prolonged half-life, improved bio-distribution, increased circulation time of the drug, controlled and sustained release of the drug, versatility of route of administration, increased intercellular concentration of drug and many more.

 

  • Magnetoelectric nanoparticles
  • Nanoparticle drug delivery
  • Problems of multidrug resistance in cancer therapies
  • Taxoids as potent cytotoxic agents for tumour targeting drug delivery
  • Epigenetic gene silencing in cancer

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