Tohid Piri-Gharaghie
Faculty of Basic Sciences, Department of Biology, Shahrekord Branch, Islamic Azad University.
Title: Identification of antigenic properties of Acinetobacter baumannii proteins as novel putative vaccine candidates using Reverse vaccinology approach
Biography
Biography: Tohid Piri-Gharaghie
Abstract
Multidrug-resistant Acinetobacter baumannii (A.baumannii) infections are becoming more prevalent all over the world. As a cost-effective and preventative method, vaccination seems to be required against this bacterium. In the present study, subtractive proteomics along with reverse vaccinology approaches was used to predict suitable therapeutics against A.baumannii. Using the Vaxign online tool, we studied over 35 genomes of A.baumannii strains and chose outer membrane and secreted proteins of A.baumannii 1656- 2 as possible vaccine candidates. Then, investigations were performed on the immunogenicity, antigenic characteristics, physicochemical properties, B-cell and MHC class I, and MHC class II molecules epitope densities of proteins.