Hasnah Osman
Universiti Sains Malaysia, Malaysia
Title: Identification of thiadiazinyl-coumarin derivatives as dengue virus-2 NS2B/NS3 protease inhibitors
Biography
Biography: Hasnah Osman
Abstract
Dengue is a dreadful arboviral disease which has become a major public health concern especially in tropical and sub-tropical regions. Despite several reports of peptide based dengue inhibitors, recently the development of small molecules against dengue has gained tremendous momentum. Moreover, selecting an accurate drug target is a critical task in finding agents with a particular biological activity that is anticipated to have therapeutic efficacy. Thus, role played by the NS2B/NS3 protein in the dengue virus life cycle is envisaged to form a potential attractive target for dengue inhibitors drug design. Coumarin analogues have received a considerable attention as a lead structure for the discovery of antiviral agents. Therefore, coumarin based thiadiazinyl hydrazones were designed as potential NS2B/NS3 protease inhibitors. Molecular docking studies provided insights into the binding modes of the inhibitors. All compounds were observed to have good interactions with the active site residues.
