Monika I Konaklieva
American University, USA
Title: A new class of b-lactam antibiotics active against drug-sensitive and drug-resistant Mycobacterium tuberculosis
Biography
Biography: Monika I Konaklieva
Abstract
We have designed, synthesized, and tested monocyclic β-lactams that carry aryl-thioether group at C4. These lactams have shown good intrinsic activity against serine β-lactamase producing Mycobacterium tuberculosis H37Rv (Mtb). Some of the compounds have demonstrated minimal inhibitory concentration (MIC) as low as 6.25 μg/ml in 7H9 and 0.19 μg/ml in GAST. Our investigations indicate that these compounds are cidal to both replicating and non-replicating persistent Mtb. These compounds have also shown activity against multi-drug resistant strains of M. tuberculosis. Therefore, they are promising candidates for lead discovery. Mechanism of action and target identification studies are currently underway.
