Christopher Hulme
The University of Arizona
United States
Title: First-in-class MCRs coupled with cascade reactions for the generation of molecular complexity
Biography
Biography: Christopher Hulme
Abstract
The discovery of complexity-generating multicomponent reactions (MCRs) is of continued interest to generate chemotypes of potential pharmacological value. This talk describes recent findings over the last 3 years primarily employing MCRs and subsequent post-condensation modifications. Valuable new insights into indole chemistry will also be presented coupled with intriguing MCR-cascade reactions. The operational simplicity and heterocyclic moieties contained in highlighted scaffolds make these protocols attractive for file enhancement, exploration of ‘drug-like’ chemical space, and medicinal chemistry campaigns