6^th World Congress on Medicinal Chemistry and Drug Design June 07-08, 2017 Milan,. Italy

Marina V Zueva has graduated from the Lomonosov Moscow State University (physiology of higher nervous activity), received her PhD and doctor of sciencernfrom Moscow Helmholtz Research Institute of Eye Diseases. Currently, she is the head of the division of Clinical Physiology of vision at the Moscow HelmholtzrnResearch Institute of Eye Diseases. She is a member of International Society of Clinical Electrophysiology of Vision (ISCEV), European Association on Vision andrnEye Research (EVER) and European Society of Retina Specialists (EURETINA). She has published over ten peer-reviewed papers in English (over 86 in Russian)rnand has presented over 65 topics at international conferences.

In 2015, the theory was proposed that links the development and maintenance of the typical in norm complex structure of neuralrnnetworks and the activity of the brain with the complexity of visual and other sensory environmental signals that affect the personrnduring the life. The theory of \'Fractality of sensations\' implies that the simplification of the temporal structure of environment cuesrnis associated with abnormal development and aging of the central nervous system. As well, the use of fractal photic stimulationrnand nonlinear stimuli of other modalities may enhance the effectiveness of strategies for a recovery in the structure and functionrnof the retina and brain, including neurodegenerative pathology, by reactivation of neuroplasticity. Application of nonlinear brainrnstimulation technology is promising in the treatment of neurological disorders and injuries to increase the effectiveness of restorationrnof the anatomic and functional structure of the brain, cognitive functions and behavior. In the spectrum of nonlinear stimulatingrntherapy techniques different variants of mono- and multimodal fractal stimulation should be used, as well as its combinations withrnwhite noise, music therapy, cognitive, and physical training. We substantiate the potential use of non-linear stimulation technologiesrnin a healthy person in a variety of situations that can lead to a simplification of the neural circuits and pattern of brain activity.rnApplication of physiologically adequate nonlinear stimuli is promising to slow and prevent age-related cognitive impairment inrnthe elderly, in rehabilitation and recovery programs for healthy individuals of certain professions associated with severe physical orrnpsychological stress, and athletes. One can expect that the use of nonlinear techniques to restore physical and mental performancernafter heavy load and effects of stress factors will help to restore the complex nonlinear dynamics of functional activity, maintaining arnhigh level of criticality and improving the adaptive brain reserve.

Kasatkin Anton, PhD, assistant of department of General and Clinical Pharmacologi Izhevsk State Medical Academy. He has published more than 65 papers inrnjournals and received 20 patents for invention. Urakov Aleksandr, MD, Prof. Head of Department of General and Clinical Pharmacologi Izhevsk State MedicalrnAcademy. He has published more than 250 papers in journals and received 100 patents for invention.

The injections of drug solutions with a high and low concentration (less than 10%) of active drug substance can be followed by therndevelopment of local inflammation and complications: cellulitis, phlegmon and necrosis. There are cases of local inflammationrnafter injection solutions of antibacterial, steroidal and non-steroidal anti-inflammatory drugs. We suggested that irritant action of thernlatter could be caused by high osmolality. The aim of this study is to investigate the local safety drug solutions with different osmolalityrnin vivo using infrared thermography. It is found that Ketorolac tromethamine osmolality index was 2971 mmol/kg, metamizolernsodium was 4520 mmol/kg and prednisolone was 4205 mmol/kg. Osmolality of sodium chloride 9 mg/ml (control solution) equaledrn305 mmol/kg. High osmolality of 50% metamizole sodium solutions was caused primarily by high concentration of active drugrnsubstance metamizole sodium (500 mg/ml) in the solution, but high osmolality of ketorolac tromethamine and prednisolone wasrndue to high total concentration of an adjuvants. Thirty minutes after injection local skin hyperthermia at the site of intramuscularrninjections of ketorolac tromethamine, metamizole sodium and prednisolone solutions were detected. Skin temperature at the site ofrninjecting these solutions was 0.6-1.4ºС higher compared with the initial values. Injections of the solutions diluted with sterile waterrnfor injections to osmolality index less than 900-1000 mmol/kg did not result in local skin hyperthermia. For safe injecting drugrnsolutions measure their osmolality should be monitored. Infrared thermography can be useful in the local drug safety assessment inrnvivo.

Alexandre Henri Didier is a post graduate student in Hospital Pharmacy since 2015. Actually he has a scholarship sponsored by his hospital and he is doing his\r\njob into the Nutrition service (Enteral and Parenteral). He has published 4 papers in reputed journals and he has taken part to more than 20 conferences during\r\n2016-2017. He has also a lot of masters in science.

Background: The pharmacology activity of corticosteroids ,is due to the formation in the blood of the complex corticosteroidprotein\r\nglycosylated, that, in this form, after the binding to the cytoplasmic receptor ,penetrates in the target cells. This interaction\r\nprocess, also happens with salivary proteins The aim of this study is, to study this process, that precipitate the salivary proteins, and\r\nwith them, the salivary secreted mucin.\r\nMaterials Methods: In two samples of whole saliva provided by volunteers ,are added different concentrations of three corticosteroids\r\n, beclometasone, budesonide, fluticasone.The samples are centrifuged, and in surnatant, dosed, the amounts of total salivary proteins\r\nand mucins.The results are statistically analyzed with Mann Whitney U Test ,Test T, pearson correlation coefficient\r\nResults –Discussion: With all dosage ,the difference of the proteins and mucins precipitated by the budesonide, and beclometasone\r\nvs fluticasone, are statistically different., p ≤ 0.05. For all three corticosteroids, there is a saturation value, with a good correlation\r\nbetween corticosteroids’s dosage and the amount of the protein-mucins precipitation, ( Pearson coefficient of 0.91).The little difference\r\nin the precipitation of the mucins,and the proteins ,p=0.0334, obtained with the budesonide versus beclometasone, can find an\r\nexplanation, for the presence in the first, of two hydroxyl groups, (one in beclometasone). The difference of beclometasone and\r\nBudesonide, versus Fluticasone, is due assuming that the parameters, that stabilize the (CCP), type hydrogen bonds and Van der\r\nWaals forces, are more influenced by solubility in water, there is nothing for the fluticasone, rather than by the chemical conformation\r\nof drugs