Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 22nd World Congress on Medicinal Chemistry and Drug Design London, UK.

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Scientific Program Day 1

Day 1 :

Keynote Forum

Tohid Piri-Gharaghie

Faculty of Basic Sciences, Department of Biology, Shahrekord Branch, Islamic Azad University.

Keynote: Identification of antigenic properties of Acinetobacter baumannii proteins as novel putative vaccine candidates using Reverse vaccinology approach
Conference Series Medicinal-Chemistry-2022 International Conference Keynote Speaker Tohid Piri-Gharaghie photo
Biography:

Professor, Biotechnology Research Center, East Tehran Branch, Islamic Azad University, Tehran Branch, Tehran, Iran and Biotechnology Research Center, Microbial Biotechnology Laboratory, BIO3P and VetCare company of AmitisGen Med TECH Group, Tehran, Iran.

 

Abstract:

Multidrug-resistant Acinetobacter baumannii (A.baumannii) infections are becoming more prevalent all over the world. As a cost-effective and preventative method, vaccination seems to be required against this bacterium. In the present study, subtractive proteomics along with reverse vaccinology approaches was used to predict suitable therapeutics against A.baumannii. Using the Vaxign online tool, we studied over 35 genomes of A.baumannii strains and chose outer membrane and secreted proteins of A.baumannii 1656- 2 as possible vaccine candidates. Then, investigations were performed on the immunogenicity, antigenic characteristics, physicochemical properties, B-cell and MHC class I, and MHC class II molecules epitope densities of proteins.