László Kollár
University of Pécs, Ifjűság u
Title: Synthesis of carboxamido steroids. Cavitand-steroid conjugates
Biography
Biography: László Kollár
Abstract
The functionalization of the androstane, estrane and pregnane skeletons, as well as the stereoselective formation of the steroidal framework by homogeneous catalytic reactions proved to be highly attractive synthetic methods [1]. Among the functional groups of pharmacological importance, the carboxamido functionality, especially in the distinguished position-3 and 17, plays an important role due to its presence in steroids with 5ï¡-reductase inhibitor properties. [2-5]
In the present contribution we report on the efficient synthesis of host compounds (cavitand–steroid conjugates) with chiral inlet bearing steroidal moieties at the upper rim of the cavitand ‘basket’. The unexpectedly high selectivity regarding the formation of tetracarboxamide, as well as the characterization and potential pharmacological applications of these compounds in ‘host-guest’ interactions will be discussed.