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Thorsten Nowak

Thorsten Nowak

C4X Discovery Manchester
UK

Title: Conformational design in medicinal chemistry - An important under-utilised opportunity

Biography

Biography: Thorsten Nowak

Abstract

With the expertise of the team from C4X Discovery, this workshop will explore how conformational insights can impact rational design in drug discovery. A brief introduction into techniques available to experimentally determine molecular conformations will follow a discussion of their associated advantages and limitations. Subsequently, control factors of conformational behavior will be introduced and their utility exemplified with case studies that will explore the principles of conformational design. The workshop participant will gain an outline understanding of the control of conformational features and how such knowledge can be used to complement alternative design strategies and technologies.