Ochieng Anthony
Sumait University
Tanzania
Title: A Comparative analysis of aspirin from various analgesic formulations using titrimetry, spectroscopic and hyphenated chromatographic techniques
Biography
Biography: Ochieng Anthony
Abstract
Aspirin, acetyl salicylic acid or 2-acetoxybenzoic acid has the carboxylic acid functional group hence easier to quantify using a strong alkali like NaOH. In most analgesic drug formulations in tablets, aspirin generally binds with other excipients or substituents which has acidic groups and easily reacts with NaOH, hence making sodium hydroxide not a suitable reagent for quantifying aspirin in analgesic tablet formulation. Six different tablets containing aspirin as active substance were taken. Methods using sodium hydroxide as the main reagent in quantification involves a lot of stoichiometric mathematical manipulations as in titrimetric, UV spectroscopy via multivariate calibration gave values at lower limit or outside the lower US & BP pharmacopeia limit while the hyphenated chromatographic techniques such as, GC-MS and HPLC gave a very good resolution and very precise results within the pharmacopeia limits.