Barbara Susana Gregori Valdes
Universidade de Lisboa
Portugal
Title: Terbinafine based Nail Lacquer for Treatment of Nail Fungal Infections
Biography
Biography: Barbara Susana Gregori Valdes
Abstract
This study focused on the synthesis and characterization of a polyurethanes to prepare a nail lacquer formulation with terbinafine hydrochloride in order to obtain a topical nail release system The synthesis of polymer was carried out by the reaction of of IPDI, PPG and isosorbide with 6:1:5 ratio, under a nitrogen atmosphere using 0.5 mL of DABCO as catalyst. The polymer was characterized by FTIR, NMR, DSC PALS and the biocompatibility with keratinocytes cell was study.The in vitro release profile of terbinafine from diferent nail lacquer formulatios was investigated using Franz Cells. The FTIR spectrum showed a band at 1695 cm-1 attributed to the stretching vibration of the C=O carbonyl of urethane. The PU melting temperature was around 60 oC. The presence of -NH protons at 5.2 and 7.5 ppm in the 1H NMR spectrum in dmso confirm the reaction between the isosorbide hydroxyl groups and the pre-polymer isocyanate groups. The PU presents cell viability measured by the MTT reduction. The release profile, demonstrated that the formulation had the ability to release the drug. In this research new polyurethane was synthesized and characterized. The polyurethane synthesized presented biocompatibility. The results so far obtained are promising for a novel terbinafine based nail lacquer for the treatment of fungal infections