Vijay Kumar Singh
Bundelkhand University
India
Title: Synthesis of some 3, 5-(di-substituted)-5-[(N-Benzotriazolomethyl) -1, 3, 4-Thiadiazolyl] - 1H-imidazole -2-thione for its Anticonvulsant activity
Biography
Biography: Vijay Kumar Singh
Abstract
Benzotriazole, Thiadiazole and Imidazole showed diversified pharmacological activity. In view of potential biological activities of Benzotriazole, Thiadiazole and Imidazole, it was considered worthwhile to synthesize some 3, 5-(di-substituted)-5-[(N-Benzotriazolomethyl) -1, 3, 4-Thiadiazolyl] - 1H-imidazole -2-thione and screen out some derivatives which show marked anticonvulsant activity. A new scheme of synthesis is designed to attach benzotriazole, thiadiazole and imidazole nuclei to form a single molecular framework (X) starting from Benzotriazole. Out of 20 synthesized derivatives three molecules show excellent anticonvulsant property. The experimental procedure has already been approved by IAEC (Institutional Animal Ethical Committee) as per the guidelines given by CPCSEA (Council for the purpose of control and supervision on experimental animals).