Medicinal Chemistry & Computer Aided Drug Designing

Biography

Biography: Divyanshu Sharma

Abstract

Various heteroannulated carbazole derivatives have drawn much attention because of their natural occurrence and the broad spectrum of biological activity associated with these compounds. In view of broad biological activity of carbazole derivatives, we planned to synthesize new carbazole derivatives by incorporating new pharmacophores such as oxadiazole, thiadiazole, azetidinone and thiazolidinone at the 9th position of carbazole nucleus with the hope to get better pharmacologically active drugs.In the same direction a one pot, comparative method was developed to synthesize a series of 5-((9H-carbazol-9-yl) methyl)-N-((substituted phenyl)-(piperazin-1-yl)methyl)-1,3,4-oxadiazol-2-aminederivatives as N-Mannich’s bases. Carbazole was taken as a starting material to react with ethylchloroacetate to produce Ethyl-N9-carbazolyl acetate(1). Compound 1 was treated withsemicarbazide to give (N9-carbazolyl acetyl)semicarbazide(2) which was then reacted with concentrated sulfuric acid to produce 5-((9H-carbazol-9-yl)methyl)-1,3,4-oxadiazol-2-amine(3). To this different aromatic aldehydes were added in the presence of piperazine to produce the corresponding 5-((9H-carbazol-9-yl)methyl)-N-((substituted phenyl)-(piperazin-1-yl)methyl)-1,3,4-oxadiazol-2-amine(4 a-j).All the synthesized compounds were checked for purity by melting point and TLC. All the synthesized compounds were characterized by FTIR, 1H NMR, MASS spectral studies and elemental analysis. Finally all the synthesized derivatives will be evaluated for their antibacterial, anticancer and anticonvulsant activities.