Byran Gowramma
JSS College of Pharmacy India
Title: SYNTHESIS & ANTI-IMFLAMMATORY SCREENING OF SOME NOVEL 2-AZETIDINONES/4-THIAZOLIDINONES BEARING 1, 3, 4-THIADIAZOLE NUCLEUS
Biography
Biography: Byran Gowramma
Abstract
The oxidative cyclization of thiosemicarbazone (I) was carried out using ferric chloride as an oxidative agent to get 2- amino- 5- styryl -1, 3, 4-thiadiazole (II). 2- amino- 5- styryl -1, 3, 4-thiadiazole (II) reacted with aromatic aldehydes in methanol to give the new product N- (4-sustituted)- 5- styryl- 1, 3, 4-thiadiazol-2-amine (IIIa-h). Compound (IIIa-h) reacted with chloroacetyl chloride in triethylamine to give 2-azetidinone derivatives bearing 1, 3, 4-thiadiazole nucleus (IVa-h). Compound (IIIa-h) on cyclo condensation with mercaptoacetic acid leads to the formation with 4-thiazolidinone derivatives bearing 1, 3, 4-thiadiazole ring (Va-h). Synthesis of all titled compounds were confirmed by melting point, IR, 1H-NMR and Mass spectrum and evaluated for their anti-inflammatory activity. Out of the synthesized compound IVa and IVb were capable of showing very good anti-inflammatory activity almost on compared with that of the standard ibuprofen, followed by IVc while the rest of compounds were found to be mild in their potency.