Yanli Wang
National Institutes of Health
USA
Title: PubChem BioAssay: a public information resource supporting medicinal chemistry and drug discovery research
Biography
Biography: Yanli Wang
Abstract
The PubChem BioAssay database, created in 2004 by National Center for Biotechnology Information (NCBI) at NIH, serves as a public repository of bioactivity data for drugs, chemical probes, small molecules, and screening results for RNAi reagents. The database currently contains over 1,000,000 bioassay protocols and more than 200 millions of bioactivity outcomes for thousands of protein and gene targets and nearly three million substances. Information in PubChem can be freely accessed and downloaded using the NCBI information retrieval system Entrezat http://www.ncbi.nlm.nih.gov/pcassay/and a suite of services provided by PubChem at http://pubchem.ncbi.nlm.nih.gov. This presentation will describe PubChem utilities. In addition, arecent bibliometric analysis on applications of the PubChem resource by the community will also be described, which indicates that PubChem has been utilized by a broad range of research fields in the past ten years, and is becoming an important information resource for a number of research fields such medicinal chemistry, drug discovery, chemical biology and cheminformatics In particularly, the analysis shows an increasing trend in supporting wet laboratory research towards lead development and drug discovery using the bioassay data. PubChem welcomes feedback on the usability of the information platform and welcomes contributions from the community by sharing data. Chemical structures and assay results can be deposited via the PubChem submission system at: http://pubchem.ncbi.nlm.nih.gov/upload