Medicinal Chemistry & Computer Aided Drug Designing

Biography

Biography: Sara Nasrollahi

Abstract

A novel method is reported for grafting of poly [N-isopropylacrylamide-co-allylglycidyl/iminodiacetic] based on iron oxide nano-particles modified by 3-mercaptopropyltrimethoxysilane. The grafted nano-polymer was characterized by elemental analysis, Fourier transform infrared spectroscopy, thermogravimetric analysis, transmission electron microscopy and scanning electron microscopy. The analytical parameters such as pH, temperature and contact time of the grafted nano-polymer were studied. Determination and extraction of famotidine in human biological fluids were evaluated with high great accessibility to the active sites in the grafted sorbent. The equilibrium adsorption data of famotidine by grafted nano-sorbent were analyzed by Langmuir and Freundlich models. The sorption capacity of the nano-sorbent was 116 mg g-1 at an optimum pH of 7. Almost 73% of famotidine was released in simulated gastric fluid in 1 h and 70% was released in simulated intestinal fluids in 30 h at 37ËšC. These results show that this new magnetic grafted nano-polymer is adequate for enteric drug delivery. The suitable cause for choosing this particular polymer was its strong retention and subsequently longer controlled release for drug delivery. In other investigation, the effect of temperature on famotidine release was evaluated. The sorption and desorption studies were carried out at five temperatures (25-45°C). The results showed that the maximum adsorption of famotidine occurred at 30°C. Because, at low temperatures, the repeating chains of N-isopropylacrylamide on the nano-sorbent were in expanded form and famotidine better loaded onto the sorbent. At high temperature the grafted polymer containing the thermo-sensitive monomer shrank, so the release of famotidine increased.