Prasad V. Bharatam
National Institute of Pharmaceutical Education and Research
India
Title: Design of Anti-Malarial Agents Using Quantum Medicinal Chemistry Methods
Biography
Biography: Prasad V. Bharatam
Abstract
The electronic structure of drugs provides several clues. The quantum chemical analysis of metformin (anti-diabetic),1,2cycloguanyl (anti-malarial),3,4 ebrotidine, famotidine (proton pump inhibitors),5,6 etc. in their protonated state were extensively studied.These provided clues regarding the electronic distribution and localization within these molecules. Further molecular docking, pharmacophore mapping and virtual screening methods were employed to design new guanylthiourea (GTU) derivatives as anti-malarial agents.7 Synthesis and biochemical evaluation of these species lead to the identification of these species as potential anti-malarial agents.8The details will be discussed in this presentation.