Call for Abstract
18th International Conference on Medicinal Chemistry & Computer Aided Drug Designing and Drug Delivery, will be organized around the theme “A Guide to Drug Discovery: The Role of Nature and Nurture in Chemistry and Targeted Drug Delivery (Smart Drug Delivery)”
MedChem and CADD 2017, USA is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in MedChem and CADD 2017, USA
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A major challenge in medicine and the biomedical sciences today is the problem of antibiotic resistance, the phenomenon by which agents of infectious diseases – bacteria being most relevant to this article – no longer respond to treatment with the ‘miracle drugs’. Let’s understand this phenomenon by tracing the roles of infectious diseases in human history; our approaches to understanding and treating them over millennia; the recent use and abuse of antibiotics and the resultant spread of antibiotic resistance; the antiquity of antibiotics in natural environments and the inevitability of resistance; and the way forward.
The design of novel drugs or of improved higher generation therapeutics is a complex task that goes beyond improving the specificity of the drug to its biological target. Since in many cases, only a minute fraction of the administered drug reaches the critical pharmacological target, strategies for increasing the drug's accumulation in the vicinity of the cellular DNA must be devised. Thus, drug delivery strategies should strive to prolong circulation time, enhance tissue-specific accumulation, increase the effectiveness of cellular and nuclear uptake in addition to high specificity and affinity towards the DNA. The complexity of the biological system makes it very difficult to simultaneously incorporate all of these factors into a single algorithm for drug design. Focusing on specificity is relatively straightforward since the structure of the DNA is well known.